By studying the remarkable properties of benzylsuccinate synthase (BSS), scientists can unlock new methods to manufacture chemicals and clean up pollutants

The natural world has a way of surprising us with its incredible solutions to complex problems. One such enzyme, benzylsuccinate synthase (BSS), has been found to possess remarkable powers that have captivated the attention of researchers in the field of chemistry. • Enzymes, such as BSS, act as molecular machines that speed up chemical reactions
• These reactions are typically triggered by mild, biologically compatible conditions, a feat that chemists strive to replicate in the lab
• BSS has been found to catalyze reactions that are particularly challenging, such as the selective formation of carbon-carbon bonds, which are essential building blocks for many valuable chemicals
The discovery of BSS has significant implications for various industries and environmental remediation. By understanding the molecular mechanisms of this enzyme, researchers can engineer enzymes for different applications. • Enzyme engineering can be used to improve chemical synthesis and manufacturing processes
• Biotechnology can be enhanced by leveraging the natural capabilities of BSS to clean up pollutants more efficiently
The research team, led by Mary C. Andorfer, PhD, has made significant breakthroughs in understanding the chemical processes that regulate free radical production and optimizing methods for measuring BSS interactions with its substrates. • Free radical production has been a major challenge in the development of BSS-based reactions
• The research group’s development of methods to generate free radicals outside of living cells has opened up new avenues for study
The study’s first author, Shukurah Anas, presents the new research at the 2025 American Society for Biochemistry and Molecular Biology Annual Meeting in Chicago. • The study’s findings have paved the way for accelerated development of BSS and similar enzymes as tools in organic synthesis, clean energy production, and environmental remediation
• Accelerated development of these enzymes could lead to more efficient and sustainable methods for manufacturing chemicals and cleaning up pollutants
As the researchers continue to refine their methods, they plan to improve upon the natural capabilities of BSS by fine-tuning properties such as enzymatic efficiency, selectivity, and stability under different temperatures. • Biotechnological applications of BSS could include the development of new enzymes for chemical synthesis and manufacturing
• Environmental remediation could also be enhanced by leveraging the power of BSS
This breakthrough has significant implications for various industries and the environment. The study’s findings have been recognized, and Shukurah Anas will present the research from 4:30 to 6:30 p.m. CDT on Sunday, April 13, at the Lakeside Center of the McCormick Place Convention Center in Chicago. • Presentation details
• Time: 4:30 p.m. CDT on Sunday, April 13
• Location: Lakeside Center of the McCormick Place Convention Center in Chicago
The American Society for Biochemistry and Molecular Biology (ASBMB) is a nonprofit scientific and educational organization with over 12,000 members worldwide. Founded in 1906, the society publishes three peer-reviewed journals and advocates for funding of basic research and education. • ASBMB’s mission
• Advancing the science of biochemistry and molecular biology
The study’s findings have the potential to revolutionize the field of chemistry and have far-reaching implications for various industries and the environment. By unlocking the secrets of BSS, scientists can develop new methods to manufacture chemicals and clean up pollutants, paving the way for a more sustainable future. • Sustainable development
• Cleaning up pollutants and manufacturing chemicals